PALI-1908

Precision Medicine Approach Fibro Stenotic Crohn’s Disease

PALI-1908: PDE4 Inhibitor Prodrug That Acts Locally at Site of Disease

PALI-1908 is a microbiota-activated PDE4 inhibitor prodrug that leverages the advancements we have made with PALI-2108 and is being developed for the treatment of fibrostenotic Crohn’s Disease.

PALI-1908 Highlights

Significant Unmet Need in Fibro Stenotic Crohn’s Disease

Currently No Approved Therapies for Fibro Stenotic Crohn’s Disease

Stenotic Crohn’s disease is a subtype of Crohn’s disease characterized by the formation of strictures or narrowing in the intestines, primarily driven by chronic inflammation and subsequent fibrosis. This chronic inflammation damages the intestinal wall, leading to the deposition of scar tissue (fibrosis), which narrows the intestinal passage and can cause bowel obstruction. As a result, patients often experience symptoms such as abdominal pain, bloating, and difficulty passing stool, significantly impacting their quality of life.

600,000 to 900,000

People in the United States have Crohn’s Disease1, 2

15-30 years

Age of Onset1, 2

$10 Billion

IBD Market Opportunity3

  1. Kappelman MD, Moore KR, Allen JK, Cook SF. Recent trends in the prevalence of Crohn’s disease and ulcerative colitis in a commercially insured US population NIH external linkDigestive Diseases and Sciences. 2013;58(2):519–525. doi:10.1007/s10620-012-2371-5
  2. Shivashankar R, Tremaine WJ, Harmsen WS, Loftus EV. Incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota from 1970 through 2010 NIH external linkClinical Gastroenterology and Hepatology. 2017;15(6):857–863. doi:10.1016/j.cgh.2016.10.039
  3. Back Bay analysis and prior work, Gastroenterology. 2019 Feb;156(3):748-764, MK Willian et al., J Patient Rep Outcomes. 2018 Dec; 2:22, Aliment Pharmacol Ther. 2010 Apr;31(7):693-707, Frontline Gastroenterol. 2021; 12(3): 207–213, Ther Clin Risk Manag. 2007 Oct; 3(5): 893–903

PDE4 Platform

Precision Medicine Approach

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