Represent a significant unmet need that can lead to chronic organ damage and dysfunction due to abnormal immune responses and persistent inflammation. These conditions often result in debilitating symptoms and a diminished quality of life for patients.

We anticipate leveraging advanced machine learning to identify patients with elevated PDE4 activity to enhance the responder population in our lead program targeting Ulcerative Colitis. By pinpointing key markers of colitis through RNA sequencing and meta-analysis, we hope to identify top PDE4-effector genes, which would enable us to predict potential patient responses to PDE4 inhibitors, ensuring targeting and effective treatment.